ADME Solutions
ADME (Drug Absorption, Distribution, Metabolism, and Excretion) represents crucial aspects of drug development, encompassing Absorption, Distribution, Metabolism, and Excretion within the body. These facets serve as pivotal indicators for evaluating a drug’s pharmacokinetic properties. LeadQuest Biotech offers comprehensive ADME solutions.
List of Service Available
- Solubility (Kinetic Solubility, Thermodynamic Solubility)
- Lipophilicity (LogD, LogP)
- Stability (Chemical Stability, Whole Blood Stability, Plasma Stability, Liver Microsome/S9 Stability, Single Enzyme Stability, Primary Hepatocyte Stability, etc.)
- Parallel Artificial Membrane Permeability Assay
- Metabolite Identification
- Drug-drug Interaction (IC50, Time-Dependent Inhibition (TDI), Inhibition Constant (Ki))
- Transporter Assays (SLC, ABC)
- Plasma/Tissue Protein Binding (Equilibrium Dialysis, Ultracentrifugation, Ultrafiltration)
- Whole Plasma Partition Coefficient
- Pharmacokinetics (PK) for Rats, Mice, and Dogs (Standard PK, Rapid PK, Box PK, Snapshot PK, Tissue Distribution, Central Nervous System (CNS) PK, Solvent Optimization)
- Acute Toxicity Assessment
- Endogenous Substance Analysis
Comprehensive Drug Efficacy Evaluation Services
