Pharmacokinetic Studies and Bioanalysis Services

LeadQuest Biotech provides customers with high-quality ADMET (ADMET stands for Absorption, Distribution, Metabolism, Excretion, and Toxicity) and pharmacokinetic services for all small molecules, including in vitro and in vivo pharmacokinetic studies as well as bioanalysis.

 

In Vivo Pharmacokinetics (PK) Test Service

• Animal Strains: Mice, Rats, Dogs (Biological analysis also available for monkeys)
• Administration Routes: Oral, Intravenous, Subcutaneous, Sublingual, Intraperitoneal, Intramuscular, Tracheal, Local Administration, etc.
• Biological Matrix: Plasma, Whole Blood, Bile, Cerebrospinal Fluid, Urine, Feces, Various Tissues, and other Homogenous Fluids, etc.
• Tissue Samples: Skin, Skeletal Muscle, Brain, Heart, Lung, Liver, Spleen, Kidney, Stomach, Abdominal and Subcutaneous Fat, Ovary, Testis, Epididymis, Small Intestine, Large Intestine, Duodenum, Knee Joints, Spinal Cord, Prostate, Sciatic Nerve, Cerebrospinal Fluid, etc.
• Administration: Single, Multiple, or Continuous Administration
• Dosage Forms: Solution, Suspension, Tablet, Capsule, Nano-Suspension, Solid Dispersion, Ointment, etc.
• Experimental Types: Complete PK, Rapid PK, Box PK, Combined Administration with Inhibitor (ABT) PK (DDI), Rapid Tissue Distribution (BBB), CNS PK, Formulation PK, PK/PD, etc.
• PK Models: Jugular Vein Cannula, Hepatic Portal Vein Cannula, Femoral Vein Cannula, Bile Duct Cannula
• PK-PD Model: CDX Model

 

Applications

• Plasma Pharmacokinetics Study
• Tissue Distribution Study
• Quantification of Metabolites
• Excretion Study
• Material Balance Analysis
• Blood-brain Barrier Assessment
• PROTAC Pharmacokinetics Study